I've got the LT version.
Gets used for every gig I do, and also for home practice too.
I also use it as my in-ear monitor feed.
Patch-wise, I have loads on there, but primarily I only use one, which I spent weeks getting exactly how I wanted it.
What drove me to get one? What piqued my interest initially was that Billy Sheehan had started using one. That guy is a total tone monster and for him to be impressed enough by it to start using one live told me it must be worth checking out.
Secondly, I'd gone back and fore between multi-fx (although mainly Boss units) and separate pedals over the years. I do like the whole separate signal paths for highs and lows type of setup (Down to Mr. Sheehan again), and the ease of setting those up in the Helix was another massive tick in the box.
I also really like that Line 6 keep putting updates out for the Helix, and also that you can share patches with fellow users on the L6 website.
Is it missing anything? The main thing I was surprised that it didn't have Bass-wise, was a Sansamp clone. Could have by now, I think I'm one or two updates behind at the moment...
YMMV, but for me it has eradicated effects GAS totally. Hope this helps!