The last time I used a 2x12 it was in late 1968. A brand new blackface/Blonde Fender Bassman. It look beautiful sitting there on stage. It was a torture I've been unable to forget. it was a weekend that seemed to last months! I took it back to the store and, as they had sold my trade in, I just left the damn thing there anyway!
That said, in todays world with modern drivers and cabinet design, I'd have no worries gigging a 2x12.