I've been happy with my Acme B2 cabinets. I have four but only use two to gig with. They are a 2x10 box and I stack a pair for a vertical 4x10. The way they handle the Low B of my sixes is a pure delight!!
If you like the sound of your Rumble practice amp why not consider one if it's bigger brothers? I've played through a Rumble 350 combo with two 10s and it handled the B of my six string with ease. It's the first Fender bass amp I've actually liked!
If the pre-amp pedal has sufficient output to drive the power amp you chose yes you can. If it doesn’t you can not!
BTW, the only dumb question is the one that was never asked.