I have occasionally considered going wireless but somehow have always shied away from it so cables it is. At the same time, I am also conscious of pulling the cable out of the amp on stage.
To that end, I have always run the guitar cable up through the handle of the cab and the amp flightcase. To compensate, I have used 30' cables so I have room to move, as it were.
In the days of the big rig (the Bass 400 and a Bass 400+ run together) I bought a Y box (which had a buffer in it).
I am now using the (active) A/E and other bases in the same band and invested in a Lehle switcher which enables me to just swap and maintain the same level (I forgot to throw the active/passive switch on the amp in a rehearsal once).
As you can imagine, being obviously the tidy sort, I thought I'd get a board for it to sit on. I also added a tuner (to use up space as much as anything) and thought I'd add the Y box to use the buffer part of it.
Lawks! What a difference. Greatly increased volume and tone. Why didn't I do that years ago? I was always aware I was losing tone but just used the tone controls to get the sound I wanted and a Bass 400 puts out enough volume so you don't have to worry. I just didn't know how much.
It was rather like listening to the Banana Boat song after the guy had 'come through the window'!