Bass > Splitter box into 2 paths.
Path 1: Over drive, modulation, synths etc - amp 1
Path 2: Compression and octaves. - amp 2
Eq each amp to suit it's role. Path 1, roll off some lows. Path 2, roll off the highs.
It works very well. I ran a split dual amp system like that for years. Now I do the same in my Helix.