I'm guessing the truly innovative stuff that suggests no influences is probably unlistenable, and rightly stays in underground scenes 😆
But I'd argue that dubstep (mid-2000s) transcended its influences enough to feel like a "new" genre, not just a variation on an old one. And in particular, the US bro-step (e.g. Skrillex) that grew out of it around 2010 - that definitely crossed over into the mainstream enough to appear in adverts and film trailers. That's usually a good sign of something that sounds novel to the average person (and also that a genre has become creatively bankrupt and all the originators have moved on 🤣).
I'm pretty out-of-touch with popular stuff now. I understand that trap has peaked in the last decade, but from what I've heard that's heavily influenced by eighties electro, so not that new - a bit like neo-soul compared to soul. I'm probably making myself sound ancient here!