[quote name='Dan Dare' timestamp='1458919518' post='3012134'] I have an overall sound I like and use that most of the time, with gentle modification to suit certain circumstances.
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This is basically what I do. Certain songs suit a more "round" tone so I'll jump to the neck pickup a bit more and vise versa for a more defined sound.
There is a lot you can change simply by changing your right hand.
If the core tone is good the rest will be good.