If you are using distortions, I;d be careful with any cabinet that has a tweeter in it - you'll probably find that you'll want to turn the tweeter level all the way down or off. If you are using the likes of the Big baby or Big Twin II, then I'd treat them more like a PA cabinet (as they do that job incredibly well) and run some sort of speaker simulator app or pedal in the effects loop before running the guitar signal out to the cabinet. You may find things sound a bit brittle and raspy without. Anyone who has plugged a high gain guitar distortion pedal straight in to a PA will know what I mean! Euurghhh!!!