I've been using Cubase a long time, so I'm very used to it. When I went to uni we recorded on Pro Tools for a while, which I really liked. There were features such as group editing that saved so much time and hassle - then I figured out Cubase has the same features, you just need to find them. Now I like them both equally as multi-track recorders. Cubase wins it for me based on it's MIDI capabilities. In terms of routing I've never felt restricted at all. If a channel has audio on it, it's an audio channel. If it's got MIDI data on it, it's a MIDI channel. If I just want a channel I can route in and out of I use "group channel". I've never bothered with effects channels or whatever the other ones are. These three types do everything I could ever want. Copying settings between channels is easy, routing I/O of all channels is very easy... I suppose it's all intuitive when you're used to it. I bought my copy 2nd hand from Ebay for about half price.
I tried Reaper on my laptop a while ago, encouraged by the comments about the "small footprint" as my laptop is lacking in power. I really struggled to understand it. I'd have done a tutorial if I had the time, and hopefully I will at some point as I'd like it to work on ideas when away from the studio
I briefly tried logic while at uni and that seemed pretty intuitive but I never got much time with it