You just gotta have a play and see what you think with your own ears!
From what I gather the roadworns have the 70's pickup placement, ie the rear pickup closer to the bridge, and the American Standards have the 60's placement.
The Roadworns have a thinner finish obviously, which some attribute to a tonal difference.
Buy yeah, you just have to sit down and compare them yourself, preferebly through your own amp, and even more preferably in a gigging enviroment, although this is usually not possible.
Si