[quote name='Doctor J' post='638742' date='Oct 28 2009, 08:08 AM']If it sounds ok acoustically then that rules out any nut or bridge issue. The nut is only a factor when you play an open string anyway. If this deadness is still there when you fret, then it's not the nut. You could swap the A and E bridge saddles too, rule out the bridge.
[b]Anyway, what might be worth trying is reversing the pickup under your E and A strings so the posts under the A string are now under the E string and vice versa. It should rule the pickup in or out as an issue fairly quickly[/b], just make sure you don't put a screw through the wire when you're seating it, it's easy to do.
On the off chance, this isn't a Rotosound string, by any chance?[/quote]
Was just about to suggest that!