My first interface was focusrite 2i2 first gen. I sold it now ☹️ it was running off the USB power and it was brilliant. My 18i8 out is better as has improved guitar recording software, but needs main power.
Anyway, if I ever needed something small I'd choose 2i2 out, never a solo, why?
One mic on amp and one di. Or one di, and one mic for vocals etc. Simple and effective. I can't comment on other brands, but if it ain't broke, don't try and fix it!