It depends on how you transport it and how careful you can trust yourself to be. Hard case, foam lightweight case, padded gig bag, no case at all... If it's going to get chucked in a van you probably want some protection, if it's being carefully carried about and never leaving your side maybe a gig bag is enough.
Whatever you do, don't take a brand new US Fender out, leaving the case in your car and think "I'll be ok carrying this back to the car to save on trips back and forth" and then tw4t it into a brick wall, removing a chunk of paint. That's not clever.