It will always depend on what kind of gigs you do, what kind of set-up you like and how much money you have to spend.
If you're a amateur playing the odd gig here and there you're going to have a different approach to a pro who plays big, well-organised gigs.
There's never been a one-size-fits-all solution to how you get heard, modelling amps, FRFR, IEMs, etc. are unlikely to change that.