I used to have Reason up until 2.5. Found it a very easy DAW to use & like Skol303, I loved that you can flip it round & route cables.
I've had several DAWs since then & if you have a Mac, then the best VFM DAW is Logic. You get a bunch of brilliant synths, drum machines & effects as well as a shed load of loops & samples. All for £150!
I'm not saying it's the best DAW (though it is my fave), the best is the one that works for You.