I have a number of Line 6 products, so here goes:
Toneport GX - Basic USB interface for recording (I use it with Cubase 4 using the POD farm modelling software). Excellent product for the price, with settings for bass, guitar and vocals.
Pocket POD Express - Used as a practice tool, much more versatile than the similarly priced Vox Amplug range (I use it with both bass and guitar). Not great tones, but fine for headphone practice.
Spider II 210 - My main guitar amp. Very good cleans and high gains for metal, piss poor lower gain settings for blues and rock (very artifical). I use it to play metal mostly so does the job well enough and with the FBV Express pedal gives me access to 4 presets, a volume/wah and pedal tuner. If you want to play thrash, it's a great amp otherwise look elsewhere.
When it came to buying a combo, I tried the Line 6 Lowdown range, a couple of Ashdowns and the Marshall MB. The Lowdown was a very versatile, good sounding amp and if you need a wide range of tones during a set, it would be a worthwhile buy, however the Marshall had the one tone I was looking for.
As with all things, you get what you pay for, but the quality of lower price range equipment has improved dramtically over the last ten years and Line 6 are no exception.