I know of countless cabs that have been delivered unboxed, straight to the stage or the recording studio without any running in. I myself delivered some cabs to Tal when she was with Jeff Beck and those cabs were unwrapped infront of her. She didn't seem to care. Whilst the science may hold true, the reality is that I don't think the average (or not so average) end user really cares.
If it was that critical, I would imagine that the driver manufacturer themselves, or at least the cab manufacturer would do the running in for you... afterall, you only get to make a first impression about a cab once. If the cab does sound noticably different, then it would be worth the aforementioned third parties time to do something about it.
Just a thought.