I frequently gig on lead guitar with single-coil-equipped guitars, and often use two drive pedals at once for solos. Against the background of the other instruments, and on a stage large enough fro me to stand more than 4ft from my amp, it is rarely a problem. I really notice the hum at home though!
However, all my basses are fully hum-cancelling, and I do remember hating audible hum when I used to gig a Jazz. As our American cousins say, go figure...