ive tried various different set ups through the years, ive gone from using no effects, to lots of effects, multi effects and now i have what i think is my settled board set up.
i use individual stop boxes rather than multieffects, i think you can be a bit more creative, but thats me.
i currently run a sansamp driver/di, distortion, delay, reverb and tuner, but i do have a flanger, over drive and compression pedal i can throw in if i really need them