Just ordered a Mac Pro (3.5Ghz 6-core), which has a 256Gb SSD, and will ship with OS Mavericks. I'll be using the latest version of Digital Performer (although also mixing in Harrison's MixBus) with my usual choice of virtual instruments/libraries, including MOTU's Mach 5 and BPM, FX Expansion's BFD3, D:Cam Synth Squad and Geist, Arturia's V-Collection and Spark Vintage, and Scuffham's S-Gear. Typically, I install the highest resolution and largest version of any virtual instrument/library. In addition to the Mac Pro I have two 2Tb CalDigit AV Drives [url="http://www.caldigit.com/avdrive/"]http://www.caldigit.com/avdrive/[/url] which are USB 3.0 enabled (although I'm considering upgrading to the AV Pro version). My interfaces of choice are RME's Fireface UC [url="http://www.rme-audio.de/en_products_fireface_uc.php"]http://www.rme-audio...fireface_uc.php[/url] (which will require a Firewire/Thunderbolt adaptor - although I'm tempted by the MADIFace XT) and Focusrite's Forte [url="http://uk.focusrite.com/usb-audio-interfaces/forte"]http://uk.focusrite....nterfaces/forte[/url] usually tracking using the 24-bit/96KHz option. I'll be abandoning physical faders and transport controls in favour of virtual, using an iPad, and mixing in the box (no outboard processing).
As I'm migrating set ups, left to my own devices, I'd most likely just organise myself the way I've always worked. But, I'd be interested to hear what others might do, by way of set up - where they would install the DAWs, virtual instruments and associated libraries, etc, etc - to optimise performance.