This is what AI says - although it may have just regurgitated the above discussion 🤣
"Yes, there can be a subtle sonic difference, with individual saddles generally providing a slightly tighter, brighter, or more focused sound, and two strings sharing a single, larger saddle (common on vintage-style bridges) potentially offering a warmer, "ballsier" tone with a more pronounced midrange.
The difference is generally minor compared to other factors like string type, pickups, or playing technique, and is largely a matter of personal preference."