I think you need to treat it like an amp and effects setup. Imagine you have an amp and some effects pedals.
firstly ignore the demo patches.
pick an amp. That’s your amp for all of your patches! One of the big issues people have is massive sonic changes between patches and this is because every patch has a different amp and cab setup. Why?
Once you have your amp, insert an effect and set it up to get a good sound. Repeat until you’re done.