My recollection is that, during the Moving Pictures tour, he turned to using Nivea soap which, whilst leaving his skin nice and soft, undermined his callouses, particularly on his 'noisemaker' finger. Historically, he had used Wright's Cold Tar soap when on tour (certainly on the 2112 and Hemisphers tours) but that was proving increasingly difficult to source in most countries, even though it was part of the band's rider. After Signals, he realised that the whole soap and callouses thing was an old wives tales and reverted to the Pears soap his mother used during his childhood in Willowdale. The impact this had on his emotional well-being was incredible and prevented the near collpase of the trio when Lifeson fell off the wagon and started smoking again.
As for his voice, Lee has, I am told, become a regular speaker at the Montreal Society Wine Drinkers and, as the MSWD has a big hall and no PA system, this has put an inordinate strain on his vocal chords. Tragic.