What's that mean "immediate signal chain"? Just a subtle way of recognising that you're going to need some digital processing at some point?
I suppose if you use a lot of digital pedals, you could argue that your signal is being sampled over and over again, creating more and more errors. You'd have to have a lot of crap pedals to hear it though.
Arguably, it would be better to plug straight into a digital multi-fx where your signal is sampled right at the start, and then processed 100% digitally until it comes out and goes to your amp, which would be just A-D-D-A. Rather than have a load of analog boutiqe pedals with a couple of digital delays at the end, where you would have A-D-D-A-A-D-D-A if you know what I mean?
Anyway, yes, I like that everyone has different opinions, otherwise we'd all sound the same, and I wouldn't feel so speshul!