I'm lefty playing righty. there was an old beat up righty acoustic in my house growing up, and the only thing i knew from watching others play was that the scratchplate was on the bottom, so thats how i picked it up. i cant play lefty to save my life.
drums are different, i can play basic beats right handed, bit if i were to ever take up drums seriously it'd be right foot bass, left hats, and open handed with remote hats and ride on the right side!
as for famous players, gary sinese (CSI, forrest gump) plays bass, but he's a righty. his bands called LT. DAN i think!