I played headline slot at a small festival in 2019 and due to a breakdown en route (car, not psychological) had to play through a small combo. It worked fine, as would have my DI box.
I have since downsized to a single 1x12 and a couple of different amp heads, much less to store, insure & carry about. The smaller option is enough for pub gigs, etc., and anything larger than that goes through the PA, making the backline irrelevant.