I have three fivers and long fingers, which suggests I prefer five?
With big hands I have no trouble playing one finger per fret up to the nut, and I actually find the extra string feels clumsier and makes muting harder (I tend to mute with fingertips not palm which limits the number of digits available). Also, I find I can play four without looking at the fingerboard as often, it's essier to get lost on a five (that said I can (debatably) play guitar with six...) They are also heavier and feel clumsier.
So why five at all?
Obviously if you want the low notes, but for most songs they are just a novelty like using an effect pedal (exceptions in our repertoire are Gasoline by Audioslave and even Devil Woman which benefits from a drop D).
Then there's the 'easier to play' argument. I found playing Pressure and Time with multiple fills in Fm easier on a five... then the band decided to play it in Em.
Finally the 'different options' argument. Well virtually all I play was originally played on four. Using a five for blues rock is fun as you do find yourself going down or across instead of up, five string is oddly suited to blues progressions. You can do a much more solid job in D. But it does feel gimmicky at othe times - I probably only use low B or C a handful of times in a night.
Really though it's all down to personal preference, I like the way five makes you think differently but it IS harder, for me at least.
It's just occurred to me that in the 90s I mostly gigged with two 24 fret basses. Now I mostly gig with fewer...