Hi.
for me, the sansamp pedal is the best £180 I ever spent. I think I liked it cos Doug Wimbish used one in Living Colour...can't remember. Anyway, I have used it in several ways: 1)as a pre-amp/DI which I have on numerous oocasions used thru a big pa at London gigs and had a monitor for my sound - this allowed a good sound without having to take an amp. 2) In studio - tone is very flexible esp as the controls are active, meaning that if you boost bass and treble, the mids will cut, and vice versa. All possibilities here coupled with the blend between the sound of your instrument and the sound of the sansamp allow a lot of possibilities. It also seems to saturate and create a tube-like sound too which is cool. 3) It is a mean fuzz pedal!!! A lot of bass distortions wimp out on the bottom end but on this you have a lot of control.
I'm no fan of line 6 pods etc and 'all in one' simulators, but if you work with sansamp you can get a lot of useable variety - it sounds good in the mix, not just the shop.
However, some may disagree!