[quote name='Ian Savage' post='1227990' date='May 11 2011, 08:26 PM']It depends on the type of effect and how you want it to affect the sound whether you run into the front end or put it in the loop; as a general rule gain-based effects like distortion and wah work best going into the front, EQ depends on what you want to do with it and time-based stuff (chorus, delay, flange etc) tend to work best in the loop (or at least after your drive effects).
Compression's a weird one, as if you're looking to smooth out the dynamics of your playing before it hits your amp and get an overall 'smoother' sound you need to run it into the front end of the amp, whereas if you're using it as speaker protection it could do with being in the loop.
Then there's the issue of what order to use the effects in which is a whole other can of worms you're highly unlikely to damage anything whatever you do though, so experiment away![/quote]
Yep that makes perfect sense, thanks for all the replies guys