Split pickup effects advice

[apl4]

Two of my basses have split-pickup outputs. My Epiphone Zenith bass and my Rickenbacker 4003 (Rick-O-Sound). I normally use a mono effects chain setup from the mono out.

In order, Tuner (Boss TU-2), Compressor (MXR M87), Distortion (Electro-Harmonix bass Big Muff Pi), Pre-Amp (Tech 21 SansAmp Bass Driver DI). I also have a Zoom B1 four multi-effects processor and a Joyo A-B selector pedal that I can use if needed.

The output then goes into either my Mark Bass Little Mark III, my Ashdown ABM C210H-500 EVO III, or direct to PA.

I want to start experimenting with a split-pickup setup. I think, using most effects on the bridge pickup and keeping the neck pickup chain minimal, but I'm not sure about compression.

What do people recommend? Most comments I have seen say just experiment, but with the number of possible combinations it's hard to know where to start.