I play a Fender Jazz through a Little Mark 3 that I usually dial in one of three ways:
1. It's pushing air and sounds like a kick drum. I like that one for super strong grooves.
2. Trebley tone, pick or no pick, something that gets more harmonic depth in it than tone 1, I use this for funk/fusiony stuff when I'm not fighting distorted guitars.
3. EQ pedal set to take the high mids and treble out so that it sounds like a P Bass, basically my P Bass button. I haven't used this one in a band yet, though.