The answer is a definite yes.
You can ditch the subs completely if you get a pair of RCF 735 or 745s. They have 15 inch woofers and high frequency drivers with BIG voice coils (3inch or 4 inch, respectively) meaning the crossover point with the woofer can be really low allowing it to almost behave like a sub in itself. Then go get yourself a good unpowered digital mixer as the RCFs are already powered, saving a load more weight again. Job done - your PA load in time is cut in half and you sacrifice nothing in terms of sound.