Yeah, the HH has lots going on. I have a lot of backline supplied for me, so typically set everything as flat as I can on the amp and use the on board pre to adjust tone. I find if I keep the bass at about 75% for every pickup selection and adjust mids and treble depending on pickup selection, I can adjust quickly enough between songs without to much dial twisting.
For switch setting 4, I turn up the mids to help get close to a precision tone, for #5 setting I drop the mids to just below the detent and increase treble a bit to help with note definition.
i couldn’t imagine making adjustments on the amp, just to much going on
Good luck